Document Type : Original Article
Authors
1
Professor of Critical Care Medicine, Department of Anesthesiology, Babol University of Medical Sciences, Babol, Iran.
2
Resident of Anesthesia, Student research committee, Babol University of medical sciences, Babol, Iran.
3
Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
4
Assistant Professor, Department of Biostatistics, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
10.22088/caspjs.2026.2068401.1029
Abstract
Introduction: Endotracheal intubation increases heart rate and blood pressure. The aim of this study is to compare the hemodynamic response of pregabalin plus fentanyl and fentanyl alone after tracheal intubation in lumbar spine surgery.
Methods: In this double-blind clinical trial study, 80 patients, 20-65 years old, who were candidates for spine surgery were randomly divided into two equal groups. Before tracheal intubation, the first group was prescribed fentanyl (F) and the second group received pregabalin and fentanyl (P). Variables including systolic blood pressure, diastolic blood pressure, heart rate at different times, and the average pain score after surgery based on the Numerical Rating Scale were recorded.
Results: The average age in the F group was 46.98 ± 8.91 and in the P group was 45.43 ± 12.49 years. The mean systolic blood pressure at different times in the two groups, analyzed by repeated measures ANOVA, showed a significant group effect (P=0.001). The average diastolic blood pressure at different times in the two groups also showed a significant group effect (P=0.002). The average heart rate one minute after induction of anesthesia was significantly higher in the F group than in the P group (P<0.001). The average pain score was 5.88 in the F group and 4.98 in the P group, which did not show a significant difference (P=0.313).
Conclusion: The results of this study showed that the hemodynamic changes after tracheal intubation in the pregabalin plus fentanyl group were less than in the fentanyl alone group.
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