Babol University of Medical Sciences Caspian Journal of Surgery 3115-9087 1 3 2025 09 01 Spindle Cell Lipoma of the Right Inguinal Canal Mimicking an Inguinal Hernia: A Case Report with Long-Term Radiologic Resolution Post-Surgery 108 112 731131 10.22088/caspjs.2025.2069361.1032 EN Hamid Shafi Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran 0000-0002-3344-923X Ghodsieh Kamrani Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran 0000-0001-6553-4693 Shiva Goharshahi Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran 0000-0001-8639-7114 Zahra Shafi Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran 0009-0003-8946-4011 Mohammad Akbari Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran 0000-0002-9406-8940 Reza Baaslroudi Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran Student Research Committee, Babol University of Medical Sciences, Babol, Iran 0009-0003-5395-7877 Journal Article 2026 02 14 Background: Spindle cell lipoma (SCL) is a rare benign neoplasm, most commonly exhibiting in the posterior neck and back of men in middle age. Inguinal canal involvement is considered rare and can clinically mimic hernias or malignancy, leading to diagnostic and management difficulties. Case Presentation: In the current paper we report the case of a 68-year-old man who presented with a progressively enlarging, non-deducible right inguinal mass extending into the scrotum over a period of 2–3 months, in contribution with lower abdominal discomfort and urinary symptoms. Initial evaluations, including imaging and laboratory tests, suggested a soft-tissue lesion without any evidence of hernia or lymphadenopathy. The patient underwent surgical excision approximately two years prior to this report. Histopathology and immunohistochemistry confirmed a diagnosis of low-grade spindle cell lipoma. Follow-up imaging, including CT, pelvic MRI, and ultrasound, showed no residual lesion or recurrence, and the patient remained clinically stable. <br><br>Conclusion: This case represents an unusual location of spindle cell lipoma with clinical presentation mimicking inguinal hernia, managed successfully with surgical excision. Long-term follow-up confirmed radiologic resolution, underscoring the benign nature of the lesion and the importance of accurate histopathological diagnosis. https://www.caspjs.com/article_731131_b66388e227f274395bf7717cb80ea8fe.pdf