Babol University of Medical Sciences Caspian Journal of Surgery 3115-9087 1 3 2025 09 01 Application of Botulinum Toxin A for Prevention of Scar Formation and Improve the Cosmetic Results in Thyroidectomy and Lateral Neck Dissection Incision Site 133 141 729742 10.22088/caspjs.2025.2069525.1034 EN Elmira Khodabakhsh Clinical Research Development Unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R. Iran 0000-0002-0429-5251 Seyed Muhammad Mehdi Ghaffari Hamedani Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran 0000-0003-4667-9824 Amirhossein Jamali Department of Operating Room, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran 0009-0007-5145-4386 Bahman Barimani Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran 0000-0002-3344-923X Abbas Alipour Community Medicine Department, Medical Faculty, Mazandaran University of Medical Sciences, Sari, Iran 0000-0003-0781-3728 Ghasem Rahmatpour Rokni Department of Dermatology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 0000-0002-5608-1167 Journal Article 2025 08 23 Background and Objective: The aim of this study was to investigate the effect of botulinum toxin injection in preventing or reducing hypertrophic scars in the incision area for individuals.<br><br>Materials and Methods: After completion of thyroidectomy surgery, half of the incision length was marked, and botulinum toxin was injected 1 cm away from the incision edges at a dose of 7.5 u/cm2. Normal saline injection was performed as a control for the other half of the incision length. Patients were photographed at 1 and 3 months post-surgery, and scars were evaluated for aesthetic parameters using the VSS system.<br><br>Results: Fourteen female participants with a mean age of 35.5 ± 7.08 years took part in this study. 11 individuals (78.6%) underwent thyroidectomy surgery. 2 patients (14.3%) underwent modified radical neck dissection (MRND), and 1 patient underwent lateral neck dissection surgery. The mean score for the area injected with botulinum toxin at 1 and 3 months follow-up was 1 and 0 respectively, while for the area injected with saline, it was 2 and 1 at 1 and 3 months (p = 0.001). In both saline and botulinum toxin groups, the score decreased significantly after 3 months (P<0.001).<br><br>Conclusion: Injection of botulinum toxin at a specific dose leads to satisfactory results in terms of aesthetic parameters, showing statistically significant differences. https://www.caspjs.com/article_729742_c7b110ada8c1632b916f235b1c58cf2e.pdf